The Rosenbaum Lab:
Membrane Protein Signaling

The Rosenbaum Lab studies the structure and function of integral membrane signaling proteins involved in human disease.

We use a diverse set of biochemical and biophysical techniques to unravel the molecular mechanisms of GPCR signaling and lipid homeostasis, and also seek to translate our fundamental insights into new therapeutic strategies.

 About the Lab

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The lab is directed by Daniel Rosenbaum at UT Southwestern Medical Center in the Department of Biophysics.

Recent Publications

Publications for homepage
Structure-Based Development of a Subtype-Selective Orexin 1 Receptor Antagonist
Structure-Based Development of a Subtype-Selective Orexin 1 Receptor Antagonist

Hellman J, Drabek M, Yin J, Gunera J, Proll T, Kraus F, Langmead CJ, Hubner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P. Proceedings of the National Academy of Sciences USA. 117: 18059-18067 (2020).

Structure of a D2 Dopamine Receptor-G-Protein Complex in a Lipid Membrane
Structure of a D2 Dopamine Receptor-G-Protein Complex in a Lipid Membrane

Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM. Nature. 584: 125-129 (2020).

Structure of an Allosteric Modulator Bound to the CB1 Cannabinoid Receptor
Structure of an Allosteric Modulator Bound to the CB1 Cannabinoid Receptor

Shao Z, Yan W, Chapman K, Ramesh K, Ferrell A, Yin J, Wang X, Xu Q, Rosenbaum DM. Nature Chemical Biology. 15: 1199-1205 (2019).

Contact

Get In Touch

Rosenbaum Lab
Department of Biophysics
University of Texas Southwestern Medical Center
North Campus ND10.504
6001 Forest Park Road
Dallas, Texas 75390